منابع مشابه
Inhibition of erbB Receptor (HER) Tyrosine Kinases as a Strategy to Abrogate Antiestrogen Resistance in Human Breast Cancer 1
It has been proposed that binding of ligand to the estrogen receptor (ER) releases its association with transcriptional corepressors, allowing the ER to recruit coactivators, which possess histone acetylase activity, and induce transcript ion of gene promoters containing estrogen response elements. It has also been proposed that the antiestrogen tamoxifen recruits t ranscript ional corepressors...
متن کاملInhibition of erbB receptor (HER) tyrosine kinases as a strategy to abrogate antiestrogen resistance in human breast cancer.
It has been proposed that binding of ligand to the estrogen receptor (ER) releases its association with transcriptional corepressors, allowing the ER to recruit coactivators, which possess histone acetylase activity, and induce transcription of gene promoters containing estrogen response elements. It has also been proposed that the antiestrogen tamoxifen recruits transcriptional corepressors to...
متن کاملThe ErbB Receptors and their Ligands
ErbB receptors are crucial for development and evolution and have been intensely pursued as targets for cancer therapeutics. Inhibiting the signaling activity of individual receptors in this family has advanced human cancer treatment. However, actual curative effects of the existing anti-ErbB therapeutics are still insufficient. A large percentage of patients who are initially responsive to Erb...
متن کاملUbiquitination and deubiquitination of ERBB receptors
Proefschrift ter verkrijging van de graad van doctor aan de Radboud Universiteit Nijmegen op gezag van de rector magnificus prof. mr. Table of contents
متن کاملThe interactome of human EGF/ErbB receptors
When you search PubMed for ‘EGF receptor’ (EGFR), the database returns more than 5000 hits. This is not entirely surprising given the receptor’s eminent role in cancer biology. However, it is truly surprising that two recent papers published by the groups of Gavin MacBeath and Matthias Mann add a whole new dimension to the problem of EGFR signaling. They do that by using protein microarray and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2000
ISSN: 1465-542X
DOI: 10.1186/bcr-2000-66654